In my 28 years as a diagnostician, the one constant I’ve seen is that they are like snowflakes – each diagnostic case is unique.
I always tell cattlemen that it’s essential to contact their veterinarian immediately – before extensive treating and before the mortality rate goes up. From there, you can work together to determine what your goals are and what questions to ask.
You and your veterinarian might turn to diagnostic tissue testing for answers, but without a few guidelines, you won’t be any closer to solving the mystery than when you started. Know what your goals are and what your diagnostic questions are.
Smart questions, smart answers
When working on a diagnostic issue, I tell those involved that the first step is to slow down and think about what questions can answer your goal for diagnostics:
- Where and how were the cattle purchased?
- How did the cattle look coming off the truck?
- Did they get vaccinated on arrival?
- Did they start eating as soon as they arrived?
- Are there ration factors to consider?
- Are there signs or symptoms of a virus circulating?
- Is there a nutritional issue, such as a mineral deficiency?
- Could we have a bovine viral diarrhea persistent infection (BVD-PI) in the group?
Once you know the diagnostic question you are asking, work together to come up with solutions for what’s going on. You’ll also want to determine if you are collecting the right tissues or samples to answer your specific question. Working with your state or regional diagnostic laboratories can be of great benefit to make sure the correct samples are collected.
If there are suspicions the issue is bovine respiratory disease (BRD), the veterinarian should conduct a postmortem exam to gather information. Your team also may decide to collect antemortem nasal or trans-tracheal wash samples for lab analysis.
A key to the success of these tissue diagnostics is to sample untreated animals, if possible. Animals that have been treated may impact diagnostic results, particularly bacterial culture. If nutritional issues are a concern, sample those animals that are clinically normal with liver biopsies. Sampling a clinically ill animal for evaluation of nutritional status may give the wrong impression of underlying factors.
Economic resources and goals are also a factor. For instance, the panel of diagnostics might be the most expensive part of a diagnostic workup. You and your veterinarian can evaluate if the cost of the test is worth the information the result will provide – is it economically feasible, and will the information answer your key questions? You’ll want to choose diagnostic tests that will give you the most usable information for your diagnostic dollar.
Remember, taking samples doesn’t necessarily mean you are delaying treatment or facing more losses. In many situations, your veterinarian may say we need to send samples to the lab to help determine what’s going on, but we are going to treat them now as well.
Management matters
But your diagnostic investigation doesn’t stop there. And it may not even start there.
One thing to remember is that there may be a management component to your diagnostic question. Pathogenic organisms can exist in animals and never cause a problem. But management changes could potentially trigger a reaction.
Various factors, such as ration changes, unvaccinated calves and changing weather patterns, can work together to create a disease scenario. For example, a ration change can disrupt rumen microflora and stimulate a metabolism change. That same ration change, tied with overcrowding, bad ventilation, storm systems and temperature variations, can cause a BRD outbreak.
Evaluating management questions and issues can help identify the correct diagnostic test and interpret the results.
Another scenario might find you dealing with a scours issue. You’ll want to remember to collect feces samples from acutely affected calves that haven’t been treated, but also carefully consider the management factors influencing the group of calves. If you have a serious, consistent scours issue, it might be caused by calving environment, cattle flow, ventilation or sanitation. In these cases, it’s often not so much the agent, but how to break the cycle of exposure to the calves.
Variation of management practices and geography across the industry makes it difficult to establish an industry-wide standard operating procedure for collecting diagnostic samples, because no question or corresponding answer will ever be the same.
It’s all up to interpretation
Finally, if tissues are sent to a lab, think about how the data will be used once it is received. Often the biggest errors are made in overinterpretation of data.
It can be tempting to lock on to a positive result and assume it’s the problem. We want easy answers and something to blame. However, the reality is there are many factors impacting each case.
In the end, it all comes down to identifying your operation’s goals. Those goals will ultimately determine which diagnostic option will yield the most useful information.
My final piece of advice is to take the basic first step. Remember, if you have a problem, call your veterinarian now. Don’t wait; delaying the involvement of your veterinarian can reduce treatment response and cost time and money.
To learn more, visit BRD-Solutions.
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Vickie Cooper
- Beef Technical Services
- Zoetis
